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Louis Nemzer, Ph.D.

Louis Nemzer
Assistant Professor
Dept. of Chemistry and Physics
(954) 262-7977 lnemzer@nova.edu

Education:

  • Ohio State University - Ph.D. - Physics, 2010
  • Ohio State University - M.S. - Physics, 2007
  • Yeshiva University (Honors) - B.A. - Physics (Math Minor), Valedictorian, 2005
    • Ph.D. Dissertation: Oxidoreductase Immobilization in Reprecipitated Polyaniline Nanostructures for Optical Biosensing Applications (Adviser: Arthur J. Epstein)
    • Undergraduate Thesis: Effect of Interface Disorder on Charge Transport through Quantum Wells

Research Interests:

  • Experimental Biophysics
  • Antibiotic Resistance in Bacteria
  • Organic Photovoltaics
  • Shannon Information Entropy in DNA

Antibiotic Resistance in Bacteria: Over time, antibiotic drugs lose potency as bacteria evolve mechanisms to resist their effects. Excessive use of antibiotics has hastened this process, as susceptible bacteria are selectively killed, allowing the resistant bacteria to proliferate. Our ongoing research attempts to identify the conditions that are most likely to give rise to antibiotic resistance. We do so using a combination of theoretical models, computer simulations, and experiments with bacteria. The goal is to discover actionable information to guide clinical decisions regarding how antibiotics are prescribed and administered.

Biomolecule Immobilization in Organic Layers: Proteins can be collected from living organisms and repurposed in electronic devices. In my research, the enzyme glucose oxidase is taken from a fungus and immobilized in a biocompatible color-changing polymer matrix. The result is a biosensor for use by diabetics to measure his or her blood-sugar in real time. I am also working on a solar cell that would take advantage of the light-harvesting protein complex found in algae, combined with the proton transporting properties of trehalose sugar-glasses.

Information Entropy of the Genetic Code: Genetic mutations in even a single letter of DNA may cause hereditary diseases, including sickle-cell anemia. However, many mutations cause no problems at all. The chance that a single nucleotide polymorphism leads to a diseased state is strongly influenced by the chemical relatedness of the amino acid originally coded and the one actually produced. Many groupings of amino acids into related “families” have been proposed. My research uses the principles of information theory – which has many mathematical connections to the physics concept of thermodynamic entropy – to examine the inherent error-correcting features of the genetic code and evaluate which groupings best take advantage of its redundancy.

Funding:

  • NSU President’s Faculty Research and Development Grant (#335347)

Advising:

  • NSU Chapter – Society of Physics Students (SPS)

Links:

Patents:

  • US Patent #8,326,389: “A System for in vivo Biosensing Based on the Optical Response of Electronic Polymers.” A novel glucose monitoring system for the real-time measurement of blood sugar in patients with diabetes

Hobbies:

  • 2014 NSU Intramural Racquetball Doubles Champion
  1. A Stochastic Cooperative Agent Model of Band-Pass Antibiotic Resistance. In Preparation
  2. Shannon Entropy of the Genetic Code and Amino Acid Families. In Preparation
  3. Imprisoned Lightning: Charge Transport in Trehalose-Derived Sugar Glasses. L R Nemzer, M S Navati, and J M Friedman. Ionics 21 2211–2217 (2015)
  4. Autism and Epilepsy. F Neymotin and L R Nemzer. Forthcoming in Children’s Health Care
  5. Contributor, The Official Guide to the MCAT® Exam (MCAT2015) 4th Edition. Association of American Medical Colleges. ISBN 9781577541332 (2014)
  6. Locus of Control and Obesity. F Neymotin and L R Nemzer. Frontiers in Endocrinology: Diabetes 5 [159] (2014)
  7. Enzyme Entrapment in Polyaniline Films Observed via Florescence Anisotropy and Antiquenching. L R Nemzer, M McCaffrey, and A J Epstein. Modern Physics Letters B 28 [11] (2014)
  8. A Model of Band-Pass Phenotypic Resistance in a Modified Beverton-Holt Framework. L R Nemzer. Mathematical Biosciences 252 7–13 (2014)
  9. Ethanol Shock and Lysozyme Aggregation. L R Nemzer, B N Flanders, J D Schmit, A Chakrabarti, and C M Sorensen. Soft Matter 9 2187–2196 (2013)
  10. Exciton Broadening in Polyaniline Chains during Ion Induced Hydrophobic Collapse and Aggregation. L R Nemzer and A J Epstein. Synthetic Metals 161 2284–2288 (2011)
  11. A Polyaniline-Based Optical Biosensing Platform Using an Entrapped Oxidoreductase Enzyme.  L R Nemzer and A J Epstein. Sensors and Actuators B: Chemical 150 376–383 (2010)
  12. Enzyme Entrapment in Reprecipitated Polyaniline Nano- and Microparticles.  L R Nemzer, A Schwartz, and A J Epstein. Macromolecules 43 4324–4330 (2010)
  13. Disorder Characterization of Oxide/Silicon Interfaces from I-V Curves. L R Nemzer and F Zypman. Mat Res Soc 786 78 (2004)
  1. 2015 Nova Southeastern University Science Colloquium Invited Talk: Antibiotic Resistance and Game Theory: Convincing Bacteria to Cheat
  2. 2015 American Physical Society (APS) March Meeting [T48.8] A Stochastic Cooperative Agent Model of Band-Pass Antibiotic Resistance
  3. 2014 Nova Southeastern University Science Week Invited Talk. Patently Non-Obvious: A Scientist Observes the US Patent System
  4. 2014 American Physical Society (APS) March Meeting [Q45.3] Enzyme Entrapment in Polyaniline Biosensors Observed via Fluorescence Anisotropy and Antiquenching
  5. 2014 Society of Physics Students (SPS) Invited Talk. The Physics of the Olympics
  6. 2013 American Physical Society (APS) March Meeting [T33.8] Charge Transport in Trehalose Sugar  Glasses
  7. 2012 Nova Southeastern University Science Week Invited Talk. Lasers, Proteins, and Alzheimer's
  8. 2012 American Physical Society (APS) March Meeting [H40.4] Lysozyme Aggregation and Fibrillation Monitored by Dynamic Light Scattering
  9. 2011 American Physical Society (APS) March Meeting [T40.2] Applied Electric Fields and the Aggregation of Highly Charged Proteins
  10. 2010 Kansas State University Department of Physics Condensed Matter Seminar: Salt-Induced Precipitation of Polyaniline for Real-Time Analyte Monitoring
  11. 2009 American Physical Society (APS) March Meeting [W18.10] An Optical Biosensing Platform using Reprecipitated Polyaniline Microparticles
  12. 2008 Condensed Matter Colloquium Ohio State University Department of Physics: Electronic and Magnetic Polymers
  13. 2008 Materials Research Society (MRS) Fall Meeting [AA8.8] A Polyaniline-Based Optical Biosensor for Continuous Glucose Monitoring
  14. 2007 Albert Einstein College of Medicine Department of Biophysics: Imprisoned Lightning: Charge Transport in Trehalose Sugar Glasses
  15. 2004 American Physical Society (APS) March Meeting [K1.73] Transport Through Disordered Silicon Oxide Quantum Structure.
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