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Richard H Perry, Ph.D.

Richard Perry
Assistant Professor
Dept. of Chemistry and Physics
(954) 262-8165 richard.perry@nova.edu

Education

2009-2012           Stanford University, Palo Alto, CA
                                    Postdoctoral Scholar, Chemistry
2004-2009           Purdue University, West Lafayette, IN
                                    Ph.D. in Chemistry received Dec. 2009
2001-2004           Florida Atlantic University, Boca Raton, FL
                                    M.S. in Chemistry received Aug. 2004
1997-2001           Florida Atlantic University, Boca Raton, FL
                                    B.S. in Biology received Aug. 2001
                                    Certificate in Biotechnology received Aug. 2001
1995-1997           University of the West Indies, Mona, Jamaica

Professional Development

2015-2016         Data Science Specialization, Coursera (created by Johns Hopkins University)
      • The Data Scientist’s Toolbox, certificate received Oct. 2015
      • R Programming, certificate received Feb. 2016

Professional Experience

2016-2016           Senior Scientist, Sancilio & Company, Inc., Riviera Beach, FL
2012-2015           Assistant Professor, University of Illinois, Urbana, IL
2009-2012           Postdoctoral Scholar, Stanford University, Palo Alto, CA
2004-2009           Research Assistant/Teaching Assistant, Purdue University, West Lafayette, IN
2001-2004           Research Assistant/Teaching Assistant, Florida Atlantic Univ., Boca Raton, FL

Research Interests

  • Development of paper-based electrochemical devices coupled to mass spectrometry (MS). Paper-based electroanalytical devices are inexpensive, portable, and versatile, making them attractive sensors for point-of-care testing and field applications.
  • Development of ionization sources capable of probing chemical reactions with high temporal resolution (typically on the order of hundreds of microseconds to a few milliseconds). These technologies enable detection of transient intermediates and they provide a snapshot of the earliest moments of a chemical reaction. Systems of interest include the reactions of organometallic catalysts and pharmaceutical drugs.
  • Development of mass spectrometry imaging (MSI) techniques and instrumentation. MSI is capable of mapping the spatial distribution and abundance of chemicals on surfaces, in biological tissues, and in cell cultures. One area of interest involves imaging lipids in biological tissues to reveal their role(s) in disease progression.
  • Characterization of ion source parameters through experiments and computer simulations with the goal of improving source design and figures of merit (e.g. sensitivity, throughput, spatial resolution, temporal resolution, and duty cycle)
  • General analytical chemistry and instrumentation including GC/MS, LC/MS, HPLC, UV/VIS, IR, and NMR.

Honors, Awards, and Recognition

2016      Article Featured on Atlas of Science
    • Recognized J. Am. Soc. Mass Spectrom. 2015, 26(10), 1702-1712.
2015      Article Featured on the Cover of the J. Am. Soc. Mass Spectrom.
    • Recognized J. Am. Soc. Mass Spectrom. 2015, 26(10), 1702-1712.
2013      Taylor Travel Award, MUACC Analytical Chemistry Conference
2012      Sniffing Out Early Reaction Intermediates, Johansson et al. PNAS USA
    • Recognized Proc. Natl. Acad. Sci. 2012, 109, 2246.
2011      Mass Spectroscopy: Investigating Intermediates, G. Armstrong, Nat. Chem.
    • Recognized Angew. Chem. Int. Ed. 2011, 50, 250.
2010      Center for Molecular Analysis and Design Fellowship, Stanford University
2008      M. G. Mellon Award in Analytical Chemistry, Purdue University
2007      Serine: Simply Sublime, M. Copsey, Chemistry World
    • Recognized Chem. Commun. 2007, 1071.
2006      Graduate Student Award for Outstanding Teaching, Purdue University
2005      Alumni Graduate Student Teaching Award, Purdue University

*Principal Investigator

  1. 1. T. J. Comi, S. W. Ryu, and R. H. Perry*, Synchronized Desorption Electrospray Ionization Mass Spectrometry Imaging, Anal. Chem. 2016, 88(2), 1169-1175. [Web]
  2. 2. Y.-M. Liu and R. H. Perry*, Paper Electrochemical Cell Coupled to Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2015, 26(10), 1702-1712. [Web]
  3. 3. K. C. Peters, T. J. Comi, and R. H. Perry*, Multistage Reactive Transmission Mode Desorption Electrospray Ionization Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2015, 26(9), 1494-1501. [Web]
  4. 4. S. E. Dubowsky, D. M. Friday, K. C. Peters, Z. Zhao, R. H. Perry, and B. J. McCall, Mass spectrometry of atmospheric-pressure ball plasmoids, Int. J. Mass Spectrom., 2015, 376, 39. [Web]
  5. K. R. Brownell, C. C. McCrory, C. E. Chidsey, R. H. Perry, R. N. Zare, R. M. Waymouth. Electrooxidation of alcohols catalyzed by amino alcohol ligated ruthenium complexes. J. Am. Chem. Soc.2013, 135, 14299-14305. [Web]
  6. R. H. Perry, D. Bellovin, E. Shroff, A. Ismail, T. Zabuawala, D. Felsher, and R. N. Zare. Characterization of MYC-Induced Tumorigenesis by in situ Lipid Profiling. Anal. Chem., 2013, 85, 4529-4262. [Web]
  7. R. H. Perry, T. J. Cahill III, J. L. Roizen, J. Du Bois, and R. N. Zare. Capturing Fleeting Intermediates in a Catalytic C-H Amination Reaction Cycle. Proc. Natl. Acad. Sci.2012, 109, 18295-18299. [Web]
  8. R. H. Perry, K. R. Brownell, K. Chingin, T. J. Cahill, R M. Waymouth, and R. N. Zare. Transient Ru-Methyl Formate Intermediates Generated with Bifunctional Transfer Hydrogenation Catalysts. Proc. Natl. Acad. Sci.2012, 109, 2246-2250. [Web]
  9. K. Chingin, R. H. Perry, S. D. Chambreau, G. L. Vagjiani, and R. N. Zare. Generation of Melamine Polymer Condensates upon Hypergolic Ignition of Dicyanamide Ionic Liquids, Angew. Chem. Int. Ed. 2011, 50, 8634-8637. [Web]
  10. R. H. Perry, M. Splendore, A. Chien, N. K. Davis, and R. N. Zare. Detecting Reaction Intermediates in Liquids on the Millisecond Time Scale Using Desorption Electrospray Ionization, Angew. Chem. Int. Ed.2011, 50, 250-254. [Web]
  11. G. K. Barbula, S. Safi, K. Chingin, R. H. Perry, and R. N. Zare. Interfacing Capillary-Based Separations to Mass Spectrometry Using Desorption Electrospray Ionization, Anal. Chem.2011, 83, 1955-1959. [Web]
  12. S. Soparawalla, G. A. Salazar, E. Sokol, R. H. Perry, and R. G. Cooks. Trace Detection of Non-Uniformly Distributed Analytes on Surfaces Using Mass Transfer and Large-Area Desorption Electrospray Ionization (DESI) Mass Spectrometry, Analyst, 2010, 135, 1953. [Web]
  13. N. L. Sanders, E. Sokol, R. H. Perry, G. Huang, and R. G. Cooks. Handheld Mass Spectrometer for Environmentally Relevant Analytes Using a Variety of Sampling and Ionization Methods, Eur. J. Mass Spectrom.2010, 16, 11. [Web]
  14. R. H. Perry, Q. Hu, R. G. Cooks, and R. J. Noll. Rephasing Ion Packets in the Orbitrap Mass Analyzer to Improve Analytical Performance, J. Am. Soc. Mass Spectrom.2009, 20, 1397. [Web]
  15. A. U. Jackson, A. Tata, C. Wu, R. H. Perry, G. Haas, L. West, and R. G. Cooks. Direct Analysis of Stevia Leaves by Desorption Electrospray Ionization Mass Spectrometry, Analyst,2009, 134, 867. [Web]
  16. S. Soparawalla, G. A. Salazar, R. H. Perry, M. Nicholas, and R. G. Cooks. Pharmaceutical Validation Using Non-Proximate Large-Area Desorption Electrospray Ionization Mass Spectrometry, Rapid Commun. Mass Spectrom.2009, 23, 1. [Web]
  17. R. H. Perry, R. G. Cooks, and R. J. Noll. Orbitrap Mass Spectrometry: Instrumentation, Ion Motion and Applications, Mass Spectrom. Rev. 2008, 27, 661. [Web]
  18. R. H. Perry, C. Wu, M. Nefliu, and R. G. Cooks. Serine Sublimes with Spontaneous Chiral Amplification, Chem. Commun.2007, 1071. [Web]
  19. W. C. Byrdwell and R. H. Perry. Liquid Chromatography with Dual Parallel Mass Spectrometry and 31P Nuclear Magnetic Resonance Spectroscopy for Analysis of Sphingomyelin and Dihydrosphingomyelin: II. Bovine Milk Sphingolipids, J. Chromatogr. A, 2007, 1146, 164. [Web]
  20. G. Wu, R. J.  RNoll, W. R. Plass, Q. Hu, R. H. Perry, and R. G. Cooks. Ion Trajectory Simulations of Axial AC Dipolar Excitation in the Orbitrap, Int. J. Mass Spectrom.2006, 254, 53. [Web]
  21. W. C. Byrdwell and R. H. Perry. Liquid Chromatography with Dual Parallel Mass Spectrometry and 31P Nuclear Magnetic Resonance Spectroscopy for Analysis of Sphingomyelin and Dihydrosphingomyelin: I. Bovine Brain and Chicken Egg Yolk, J. Chromatogr. A, 2006, 1133, 149. [Web
*Principal Investigator; First Author Presented
  1. R. H. Perry*. Development of multistage reactive transmission mode desorption electrospray ionization mass spectrometry for characterizing complex catalytic reactions. ACS 248th National Conference, San Francisco, CA, 2014. (Invited Talk)
  2. R. H. Perry*. Fast-Moving Ambient Microdroplets for Studying Reaction Mechanisms in Solution. Murray State University, Murray, KY, 2014. (Invited Talk)       
  3. R. H. Perry*. Pulsed Desorption Electrospray Ionization Mass Spectrometry Imaging. 2014 Analytix Conference, Dalian, China, 2014. (Invited Talk)
  4. R. H. Perry*. Multi-Stage Reactive Transmission Mode Desorption Electrospray Ionization. 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, 2014.
  5. R. H. Perry*. Pulsed Desorption Electrospray Ionization Mass Spectrometry Imaging. Midwestern Universities Analytical Chemistry Conference, South Bend, IN, 2013(Taylor Travel Award Lecture)
  6. R. H. Perry*. Pulsed Desorption Electrospray Ionization Mass Spectrometry Imaging. American Chemical Society Midwest Regional Meeting, Springfield, MO, USA, 2013 (Invited Talk)
  7. R. H. Perry, K. Chingin, and R. N. Zare. Detecting Transient Organometallic Catalytic Intermediates on the Millisecond Timescale Using Desorption Electrospray Ionization. 59th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, 2011.
  8. R. H. Perry, M. Splendore, A. Chien, N. K. Davis, and R. N. Zare. Detecting Reaction Intermediates in Liquids on the Millisecond Time Scale Using Desorption Electrospray Ionization. 26th Asilomar Conference on Mass Spectrometry, Pacific Grove, CA, 2010.
  9. R. H. Perry, Q. Hu, G. A. Salazar, R. G. Cooks, and R. J. Noll. Ion-Ion Interactions in the Orbitrap Mass Analyzer. 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, PA, 2009.
  10. R. H. Perry, G. A. Salazar, R. J. Noll, W. R. Plass, and R. G. Cooks. Space Charge Effects and Ion Motion Control in the Orbitrap Mass Analyzer. 35th FACSS Conference, Reno, NV, 2008.
  11. R. H. Perry, G. A. Salazar, R. J. Noll, W. R. Plass, and R. G. Cooks. Studies of Space Charge Effects in the Orbitrap Mass Analyzer. 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, 2008.
  12. R. H. Perry, Q. Hu, L. Gao, I. Zhang, R. J. Noll, and R. G. Cooks. Phase-Enhanced Selective Ion Ejection in an Orbitrap Mass Spectrometer. 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, 2007.
  13. R. H. Perry, W. C. Byrdwell, and D. Borchman. Changes in the Phospholipid Composition of the Human Lens with Age and Cataract Formation. Association for Research in Vision and Ophthalmology Annual Meeting, Fort Lauderdale, FL, 2003.

*Principal Investigator; First Author Presented

  1. T. J. Comi, R. H. Perry*. Pulsed Desorption Electrospray Ionization Mass Spectrometry Imaging. 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, 2014.
  2. H. M. Robison, T. J. Comi, S. W. Ryu; R. H. Perry*. Lipidomic Classification of Human Mammary Cancer Cells According to Metastatic Potential and Oncogene Expression by Desorption Electrospray Ionization Mass Spectrometry. 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, 2014.
  3. K. C. Peters, K. Parker, R. H. Perry*. Characterizing High-Valent Iron Porphyrin C-H Hydroxylation Reactions by Reactive Transmission Mode Desorption Electrospray Ionization Mass Spectrometry. 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, 2014.
  4. H. M. Robison, T. J. Comi, S. W. Ryu; R. H. Perry*. Lipidomics on Intact Breast Cancer Cell Lines Using Desorption Electrospray Ionization Mass Spectrometry. Pittcon Conference and Expo, Chicago, IL, 2014.
  5. K. C. Peters, K. Parker, R. H. Perry*. Combining Desorption and Extractive Electrospray Ionization Sources to Intercept Transient High-Valent Iron Oxo Catalytic Intermediates. Pittcon Conference and Expo, Chicago, IL, 2014.
  6. T. J. Comi, R. H. Perry*. Pulsed Desorption Electrospray Ionization Mass Spectrometry. Pittcon Conference and Expo, Chicago, IL, 2014.
  7. K. Chingin, R. H. Perry, S. D. Chambreau, G. L. Vaghjianai and R. N. Zare. Generation of Melamine Polymer Condensates Upon Hypergolic Ignition of Dicyanamide Ionic Liquids. 59th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, 2011.
  8. K. Chingin, R. H. Perry, G. K. Barbula, and R. N. Zare. High-Throughput Screening of Organometallic Reactions by Desorption Electrospray Ionization (DESI), 26th Asilomar Conference on Mass Spectrometry, Pacific Grove, CA, 2010.
  9. R. G. Cooks, A. B. Costa, M. Nefliu, and R. H. Perry. The Homochiral Serine Octamer and the Origin of Homochirality. 238th ACS National Meeting & Exposition, Washington, DC, 2009.
  10. A. B. Costa, M. Nefliu, R. H. Perry, V. J. Hall, G. J. Simpson, and R. G. Cooks. Structure and Behavior of Serine Clusters in Solution and Gas-Phase. 238th ACS National Meeting & Exposition, Washington, DC, 2009.
  11. G. A. Salazar, R. H. Perry, and R. G. Cooks. Analysis of Large Surface Areas by Desorption Electrospray Ionization (DESI). 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, 2008.
  12. R. J. Noll, R. H. Perry, G. A. Salazar, Q. Hu, G. Wu, G. and R. G. Cooks. Ion Motion Control in the Orbitrap Mass Analyzer. Delaware Mass Spectrometry Discussion Group, Villanova, PA, 2008.
  13. M. Nefliu, R. H. Perry, C. Wu, S. Bird, D. E. Clemmer, and R. G. Cooks. Online Mass Spectrometric Investigation of Chiral Amplification of Amino Acid Sublimates. Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, 2007.
  14. R. J. Noll, Q. Hu, R. H. Perry, G. Wu, W. R. Plass, and R. G. Cooks. Driving Ion Axial Motion in the Orbitrap Mass Analyzer. Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, 2006.
  15. Q. Hu, R. H. Perry, G. Wu, W. R. Plass, R. J. Noll, and R. G. Cooks. Ion Motion Control Experiments and Simulations in the Orbitrap Mass Analyzer. Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, 2006.
  16. W. C. Byrdwell and R. H. Perry. Dual Parallel Mass Spectrometers with 31P NMR for Sphingolipid Analysis. 97th Annual Meeting of the American Oil Chemists’ Society, St. Louis, MO, 2005.
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