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Louis Nemzer, Ph.D.

Louis Nemzer
Associate Professor
Dept. of Chemistry and Physics
(954) 262-7977


  • Ohio State University - Ph.D. - Physics, 2010
  • Ohio State University - M.S. - Physics, 2007
  • Yeshiva University (Honors) - B.A. - Physics (Math Minor), Valedictorian, 2005
    • Ph.D. Dissertation: Oxidoreductase Immobilization in Reprecipitated Polyaniline Nanostructures for Optical Biosensing Applications (Adviser: Arthur J. Epstein)
    • Undergraduate Thesis: Effect of Interface Disorder on Charge Transport through Quantum Wells

Research Interests:

  • Experimental Biophysics
  • Antibiotic Resistance in Bacteria
  • Seizure Prediction
  • Shannon Information Entropy in DNA

Antibiotic Resistance in Bacteria: Over time, antibiotic drugs lose potency as bacteria evolve mechanisms to resist their effects. Excessive use of antibiotics has hastened this process, as susceptible bacteria are selectively killed, allowing the resistant bacteria to proliferate. Our ongoing research attempts to identify the conditions that are most likely to give rise to antibiotic resistance. We do so using a combination of theoretical models, computer simulations, and experiments with bacteria. The goal is to discover actionable information to guide clinical decisions regarding how antibiotics are prescribed and administered.

Seizure Prediction: Real-time detection and prediction of seizures in patients with epilepsy is essential for rapid intervention. We use a computer simulation of networks of neurons to generate artificial EEG signals. We find that situations corresponding to interictal (non-seizure) and ictal (seizure) states are separated by a phase transition that can be influenced by congenital channelopathies, anticonvulsant drugs, and connectome plasticity. The interictal phase exhibits scale-free phenomena, as characterized by a power law form of the spectral power density, while the ictal state suffers from pathological synchronization. We compare the results with intracranial EEG data and show how these findings may be used to detect or even predict seizure onset.

Biomolecule Immobilization in Organic Layers: Proteins can be collected from living organisms and repurposed in electronic devices. In my research, the enzyme glucose oxidase is taken from a fungus and immobilized in a biocompatible color-changing polymer matrix. The result is a biosensor for use by diabetics to measure his or her blood-sugar in real time. I am also working on a solar cell that would take advantage of the light-harvesting protein complex found in algae, combined with the proton transporting properties of trehalose sugar-glasses.

Information Entropy of the Genetic Code: Genetic mutations in even a single letter of DNA may cause hereditary diseases, including sickle-cell anemia. However, many mutations cause no problems at all. The chance that a single nucleotide polymorphism leads to a diseased state is strongly influenced by the chemical relatedness of the amino acid originally coded and the one actually produced. Many groupings of amino acids into related “families” have been proposed. My research uses the principles of information theory – which has many mathematical connections to the physics concept of thermodynamic entropy – to examine the inherent error-correcting features of the genetic code and evaluate which groupings best take advantage of its redundancy.


  1. Interictal to Ictal Phase Transition in a Small-World Network. In Preparation
  2. Ultrasensitive Growth in a Volunteer’s Dilemma Mediated by an Impure Public Good. In Preparation
  3. 3D-Printing and Data Visualization. Under Review at Journal of Information and Knowledge Management
  4. A Binary Representation of the Genetic Code. L R Nemzer BioSystems 155 10–19 (2017)
  5. Shannon Information Entropy in the Canonical Genetic Code.
    L R Nemzer Journal of Theoretical Biology 415 158–170 (2017)
  6. Linking Autism and Epilepsy. F Neymotin and L R Nemzer. Children’s Health Care 45 [1] (2016)
  7. Imprisoned Lightning: Charge Transport in Trehalose-Derived Sugar Glasses.
    L R Nemzer, M S Navati, and J M Friedman. Ionics 21 2211–2217 (2015)
  8. The Official Guide to the MCAT® Exam (MCAT2015) 4th Edition.
    Association of American Medical Colleges. ISBN 9781577541332 (2014), Participating Author.
  9. Locus of Control and Obesity.
    F Neymotin and L R Nemzer. Frontiers in Endocrinology: Diabetes 5 [159] (2014)
  10. Enzyme Entrapment in Polyaniline Films Observed via Fluorescence Anisotropy and Antiquenching.
    L R Nemzer, M McCaffrey, and A J Epstein. Modern Physics Letters B 28 [11] (2014)
  11. A Model of Band-Pass Phenotypic Resistance in a Modified Beverton-Holt Framework.
    L R Nemzer. Mathematical Biosciences 252 7–13 (2014)
  12. Ethanol Shock and Lysozyme Aggregation. L R Nemzer, B N Flanders, J D Schmit, A Chakrabarti,and C M Sorensen. Soft Matter 9 2187–2196 (2013)
  13. Exciton Broadening in Polyaniline Chains during Ion Induced Hydrophobic Collapse and Aggregation.
    L R Nemzer and A J Epstein. Synthetic Metals 161 2284–2288 (2011)
  14. A Polyaniline-Based Optical Biosensing Platform Using an Entrapped Oxidoreductase Enzyme.
    L R Nemzer and A J Epstein. Sensors and Actuators B: Chemical 150 376–383 (2010)
  15. Enzyme Entrapment in Reprecipitated Polyaniline Nano- and Microparticles.
    L R Nemzer, A Schwartz, and A J Epstein. Macromolecules 43 4324–4330 (2010)
  16. Disorder Characterization of Oxide/Silicon Interfaces from I-V Curves.
    L R Nemzer and F Zypman. Mat Res Soc 786 78 (2004)


2017 American Physical Society (APS) March Meeting [R5.6] Interictal to Ictal Phase Transition in a
               Small-World Network

2016 Interdisciplinary Council for the Study of Autism Invited Talk: Linking Autism and Epilepsy

2015 Nova Southeastern University Science Colloquium Invited Talk:

              Antibiotic Resistance and Game Theory: Convincing Bacteria to Cheat

2015 American Physical Society (APS) March Meeting [T48.8] A Stochastic Cooperative Agent Model
              of Band-Pass Antibiotic Resistance

2014 Nova Southeastern University Science Week Invited Talk. Patently Non-Obvious:
         A Scientist Observes the US Patent System

2014 American Physical Society (APS) March Meeting [Q45.3] Enzyme Entrapment in Polyaniline Biosensors

         Observed via Fluorescence Anisotropy and Antiquenching

2014 Society of Physics Students (SPS) Invited Talk. The Physics of the Olympics

2013 American Physical Society (APS) March Meeting [T33.8] Charge Transport in Trehalose Sugar Glasses

2012 Nova Southeastern University Science Week Invited Talk.  Lasers, Proteins, and Alzheimer's

2012 American Physical Society (APS) March Meeting [H40.4] Lysozyme Aggregation and Fibrillation

         Monitored by Dynamic Light Scattering

2011 American Physical Society (APS) March Meeting [T40.2] Applied Electric Fields and the

        Aggregation of Highly Charged Proteins

2010 Kansas State University Department of Physics Condensed Matter Seminar: Salt-Induced

         Precipitation of Polyaniline for Real-Time Analyte Monitoring

2009 American Physical Society (APS) March Meeting [W18.10] An Optical Biosensing Platform

         using Reprecipitated Polyaniline Microparticles

2008 Condensed Matter Colloquium Ohio State University Department of Physics: Electronic and

         Magnetic Polymers

2008 Materials Research Society (MRS) Fall Meeting [AA8.8] A Polyaniline-Based Optical Biosensor

         for Continuous Glucose Monitoring

2007 Albert Einstein College of Medicine Department of Biophysics: Imprisoned Lightning: Charge

        Transport in Trehalose Sugar Glasses

2004 American Physical Society (APS) March Meeting [K1.73] Transport Through Disordered

        Silicon Oxide Quantum Structures



  • NSU President’s Faculty Research and Development Grant (#335347)


  • NSU Chapter – Society of Physics Students (SPS)



  • US Patent #8,326,389: “A System for in vivo Biosensing Based on the Optical Response of Electronic Polymers.” A novel glucose monitoring system for the real-time measurement of blood sugar in patients with diabetes


  • 2014 NSU Intramural Racquetball Doubles Champion
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